Article

LCM-seq reveals unique transcriptional adaption mechanisms of resistant neurons in spinal muscular atrophy

2018-06-27

Abstract excerpt

Somatic motor neurons are selectively vulnerable in spinal muscular atrophy (SMA), a lethal disease caused by a deficiency of the ubiquitously expressed survival of motor neuron (SMN) protein. However, some brainstem motor neuron groups, including oculomotor and trochlear (ocular), which innervate the muscles around the eyes, are for unknown reasons spared. Here, using laser capture microdissection coupled with RN...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8558fbfa-bbf8-5173-8679-21328b2a38f1
DOI: 10.1101/356113

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

LCM-seq reveals unique transcriptional adaption mechanisms of resistant neurons in spinal muscular atrophyDOI 10.1101/356113Read

LCM-seq reveals unique transcriptional adaptation mechanisms of resistant neurons and identifies protective pathways in spinal muscular atrophy.Semantic proximity Read

Transcriptional modulation unique to vulnerable motor neurons predicts ALS across species and SOD1 mutationsSemantic proximity Read

Transcriptional modulation unique to vulnerable motor neurons predicts ALS across species and SOD1 mutations.Semantic proximity Read

Comparison of independent screens on differentially vulnerable motor neurons reveals alpha-synuclein as a common modifier in motor neuron diseases.Semantic proximity Read

Unravelling the enigma of selective vulnerability in neurodegeneration: motor neurons resistant to degeneration in ALS show distinct gene expression characteristics and decreased susceptibility to excitotoxicity.Semantic proximity Read

Single-cell RNA-seq analysis of the brainstem of mutant SOD1 mice reveals perturbed cell types and pathways of amyotrophic lateral sclerosis.Semantic proximity Read

Synaptotagmin 13 is neuroprotective across motor neuron diseasesSemantic proximity Read

An emergent disease-associated motor neuron state precedes cell death in a mouse model of ALSSemantic proximity Read

Spatial transcriptomics identifies dysregulated programs across neural and non-neural tissues in spinal muscular atrophySemantic proximity Read

Dysregulation of synaptogenesis genes antecedes motor neuron pathology in spinal muscular atrophySemantic proximity Read

Single-nucleus sequencing reveals enriched expression of genetic risk factors in Extratelencephalic Neurons sensitive to degeneration in ALSSemantic proximity Read

Genome-wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular AtrophySemantic proximity Read