Article

RUNX1 and YY1 modulate neuronal fate and energy metabolism in Alzheimer's disease

2026-04-14

Abstract excerpt

Loss of neuronal identity and metabolic dysfunction are features of Alzheimer's disease (AD), yet the upstream-acting molecular drivers remain incompletely understood. By integrating multi-omics data from patient-derived induced neurons (iNs) and AD post-mortem human brains, we discovered that AD neurons express two master transcription factors (TFs), RUNX1 and YY1. While these TFs are primarily expressed during d...

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Literature Corpus work: f770f06f-7965-52cb-b688-9c08e2eba4bb
DOI: 10.64898/2026.04.13.716801

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