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Molecular Insights into the Pathogenesis of Alzheimer's Disease and Its Relationship to Normal Aging

28 Dec 2011

Abstract excerpt

Alzheimer's disease (AD) is a complex neurodegenerative disorder that diverges from the process of normal brain aging by unknown mechanisms. We analyzed the global structure of age- and disease-dependent gene expression patterns in three regions from more than 600 brains. Gene expression variation could be almost completely explained by four transcriptional biomarkers that we named BioAge (biological age), Alz...

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PMID: 22216330
DOI: 10.1371/journal.pone.0029610

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