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Sex differences in Alzheimer’s disease: metabolic reprogramming and therapeutic intervention

13 Oct 2021

Abstract excerpt

Studies on the sporadic form of Alzheimer's disease (AD) have revealed three classes of risk factor: age, genetics, and sex. These risk factors point to a metabolic dysregulation as the origin of AD. Adaptive alterations in cerebral metabolism are the rationale for the Metabolic Reprogramming (MR) Theory of the origin of AD. The theory contends that the progression toward AD involves three adaptive events: a...

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PMID: 34654630
DOI: 10.1016/j.tem.2021.09.004

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