Article

Uev1A counteracts oncogenic <i>Ras</i> stimuli in both polyploid and diploid cells

2025-04-23

Abstract excerpt

Oncogenic Ras is known to induce DNA replication stress, leading to cellular senescence or death. In contrast, we found that it can also trigger polyploid Drosophila ovarian nurse cells to die by inducing aberrant division stress. To explore intrinsic protective mechanisms against this specific form of cellular stress, here we conducted a genome-wide genetic screen and identified the E2 enzyme Uev1A as a key pro...

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Literature Corpus work: f75cebca-1c43-5b40-9252-11afe7150773
DOI: 10.1101/2025.04.17.649440

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