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Distinct and redundant functions of cyclin E1 and cyclin E2 in development and cancer

1 Jan 2010

Abstract excerpt

The highly conserved E-type cyclins are core components of the cell cycle machinery, facilitating the transition into S phase through activation of the cyclin dependent kinases, and assembly of pre-replication complexes on DNA. Cyclin E1 and cyclin E2 are assumed to be functionally redundant, as cyclin E1-/- E2-/- mice are embryonic lethal while cyclin E1-/- and E2-/- single knockout mice have primarily normal...

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PMID: 20180967
DOI: 10.1186/1747-1028-5-2

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