Article
Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines.
Nature - 20 Sept 2001
Moberg K H, Bell D W, Wahrer D C, Haber D A, Hariharan I K
Abstract excerpt
During Drosophila development and mammalian embryogenesis, exit from the cell cycle is contingent on tightly controlled downregulation of the activity of Cyclin E-Cdk2 complexes that normally promote the transition from G1 to S phase. Although protein degradation has a crucial role in downregulating levels of Cyclin E, many of the proteins that function in degradation of Cyclin E have not been identified. In a...
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