Article

Paradoxical activation of oncogenic signaling as a cancer treatment strategy

2023-02-07

Abstract excerpt

<h4>ABSTRACT</h4> Cancer homeostasis depends on a balance between activated oncogenic pathways driving tumorigenesis and engagement of stress-response programs that counteract the inherent toxicity of such aberrant signaling. While inhibition of oncogenic signaling pathways has been explored extensively, there is increasing evidence that overactivation of the same pathways can also disrupt cancer homeostasis and...

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Literature Corpus work: 68b02c8d-057b-5fc4-a744-0ca3d67576cd
DOI: 10.1101/2023.02.06.527335

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