Article

USP28 and SPINT2 mediate cell cycle arrest after whole genome doubling

2020-09-18

Abstract excerpt

Tetraploidy is frequent in cancer and whole genome doubling shapes the evolution of cancer genomes, thereby driving the transformation, metastasis and drug resistance. Yet, human cells usually arrest when they become tetraploid due to p53 activation that leads to CDKN1A expression, cell cycle arrest, senescence or apoptosis. To uncover the barriers that block proliferation of tetraploids, we performed an RNAi medi...

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Literature Corpus work: eb8b4603-1d25-5d52-aa31-9289317ff3df
DOI: 10.1101/2020.09.18.303834

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