Article

Replicative stress in gastroesophageal adenocarcinoma is associated with chromosomal instability and sensitivity to DNA damage response inhibitors

2023-03-28

Abstract excerpt

<h4>SUMMARY</h4> Gastroesophageal adenocarcinoma (GEA) is an aggressive, often lethal, malignancy that displays marked chromosomal instability (CIN). To understand adaptive responses that enable CIN, we analyzed paired normal, premalignant, and malignant gastric lesions from human specimens and a carcinogen-induced mouse model, observing activation of replication stress, DNA damage response (DDR), and cell cycle...

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Literature Corpus work: 79e00dec-2e30-5578-9106-88051cab0162
DOI: 10.1101/2023.03.27.534412

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