Article

Polysialylation is a general feature of immune activation

2025-01-14

Abstract excerpt

Sialic acids are critical regulators of immune responses and the sialic acid-Siglec axis has receive much attention recently for it role as a new immune checkpoint. While α2,3- and α2,6-linked sialosides have been well studied, much less is known about the α2,8-linked polysialic acid (polySia), especially in the adaptive immune system. We demonstrate here that polySia is actually found in all major classes of circ...

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Literature Corpus work: 61b69c15-6f22-5228-9cf8-da32c29c63d2
DOI: 10.1101/2025.01.10.632476

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