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Article

Characterisation of genetic variation in ST8SIA2 and its interaction region in NCAM1 in patients with bipolar disorder.

PloS one - 1 Jan 2014

Shaw Alex D, Tiwari Yash, Kaplan Warren, Heath Anna, Mitchell Philip B, Schofield Peter R, Fullerton Janice M

Abstract excerpt

Alpha-2,8-sialyltransferase 2 (ST8SIA2) is an enzyme responsible for the transfer of polysialic acid (PSA) to glycoproteins, principally the neuronal cell adhesion molecule (NCAM1), and is involved in neuronal plasticity. Variants within ST8SIA2 have previously shown association with bipolar disorder, schizophrenia and autism. In addition, altered PSA-NCAM expression in brains of patients with schizophrenia or...

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Source

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Identifiers

PMID: 24651862
DOI: 10.1371/journal.pone.0092556
PMCID: PMC3961385

Genes

NCAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterisation of genetic variation in ST8SIA2 and its interaction region in NCAM1 in patients with bipolar disorder.PMID 24651862Read ↗

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