Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A cancer-unique glycan: de-N-acetyl polysialic acid (dPSA) linked to cell surface nucleolin depends on re-expression of the fetal polysialyltransferase ST8SIA2 gene

20 Sept 2021

Abstract excerpt

BACKGROUND: Polysialic acid (polySia) modifies six cell surface proteins in humans mainly during fetal development and some blood cells in adults. Two genes in humans, ST8SIA2 and ST8SIA4, code for polysialyltransferases that synthesize polySia. ST8SIA2 is highly expressed during fetal development and in cancer but not in adult normal human cells. ST8SIA4 is expressed in fetal and adult brain, spleen, thymus, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Glycosylation and Glycoproteins Research
Share to Proteoglycans and glycosaminoglycans research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34544457
DOI: 10.1186/s13046-021-02099-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A cancer-unique glycan: de-N-acetyl polysialic acid (dPSA) linked to cell surface nucleolin depends on re-expression of the fetal polysialyltransferase ST8SIA2 genePMID 34544457Read ↗

A cancer-unique glycan: de-N-acetyl polysialic acid (dPSA) linked to cell surface nucleolin depends on re-expression of the fetal polysialyltransferase ST8SIA2 geneSemantic proximity Read ↗

Impact of structural aberrancy of polysialic acid and its synthetic enzyme ST8SIA2 in schizophreniaSemantic proximity Read ↗

Effects of intronic single nucleotide polymorphisms (iSNPs) of a polysialyltransferase, ST8SIA2 gene found in psychiatric disorders on its gene products.Semantic proximity Read ↗

Relationship between ST8SIA2, polysialic acid and its binding molecules, and psychiatric disorders.Semantic proximity Read ↗

Protein glycosylation in cancers and its potential therapeutic applications in neuroblastomaSemantic proximity Read ↗

Aberrant sialylation in a patient with a HNF1α variant and liver adenomatosisSemantic proximity Read ↗

Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockadeSemantic proximity Read ↗

NANS-mediated synthesis of sialic acid is required for brain and skeletal development.Semantic proximity Read ↗

Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation.Semantic proximity Read ↗

Sialyltransferase ST8Sia-II assembles a subset of polysialic acid that directs hippocampal axonal targeting and promotes fear behavior.Semantic proximity Read ↗

Sialylation is involved in cell fate decision during development, reprogramming and cancer progressionSemantic proximity Read ↗

ST8SIA4-mediated polysialylation is critical for CCR2-driven monocyte egress from the bone marrowSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.