Article

Cellular modifiers of TDP-43 phase transition and cytoplasmic aggregation

2025-12-17

Abstract excerpt

RNA-binding protein TAR DNA-binding protein 43 (TDP-43) can form liquid-like, nuclear assemblies whose phase behavior is thought to influence its aggregation propensity and neurotoxic activity. The mechanism(s) that governs the liquid-to-solid phase transition of TDP-43 is poorly defined. Here we combined chemical and genome-wide genetic screenings to identify cellular factors that modulate the phase behavior of a...

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Literature Corpus work: eea10087-3ed3-50e3-b2e3-b5f9ee3386cb
DOI: 10.64898/2025.12.16.694670

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