Article
A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation.
Cell - 27 Aug 2015
Patel Avinash, Lee Hyun O, Jawerth Louise, Maharana Shovamayee, Jahnel Marcus, Hein Marco Y, Stoynov Stoyno, Mahamid Julia, Saha Shambaditya, Franzmann Titus M, Pozniakovski Andrej, Poser Ina, Maghelli Nicola, Royer Loic A, Weigert Martin, Myers Eugene W, Grill Stephan, Drechsel David, Hyman Anthony A, Alberti Simon
Abstract excerpt
Many proteins contain disordered regions of low-sequence complexity, which cause aging-associated diseases because they are prone to aggregate. Here, we study FUS, a prion-like protein containing intrinsically disordered domains associated with the neurodegenerative disease ALS. We show that, in cells, FUS forms liquid compartments at sites of DNA damage and in the cytoplasm upon stress. We confirm this by...
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