Article

Predicting the spectrum of TCR repertoire sharing with a data-driven model of recombination

2018-03-02

Abstract excerpt

Despite the extreme diversity of T cell repertoires, many identical T cell receptor (TCR) sequences are found in a large number of individual mice and humans. These widely-shared sequences, often referred to as ‘public‘, have been suggested to be over-represented due to their potential immune functionality or their ease of generation by V(D)J recombination. Here we show that even for large cohorts the observed deg...

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Literature Corpus work: f72fb45d-488b-5ca6-ac1b-255347cba599
DOI: 10.1101/275602

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