Article

MED8 Couples Mediator-Dependent Transcriptional Plasticity with Mesenchymal-Immune Remodeling in Diffuse Glioma

2026-07-23

Abstract excerpt

<title>Abstract</title> <p>Purpose Diffuse gliomas remain lethal because malignant-state plasticity, immune suppression, and treatment resistance are interlocked within the tumor ecosystem. The Mediator complex links enhancer-bound transcription factors to RNA polymerase II, yet the relevance of the Mediator head-module subunit MED8 in glioma remains unclear. This study tested whether MED8 marks and functionally...

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Literature Corpus work: f72db251-8a46-5a1a-9102-106635ea946e
DOI: 10.21203/rs.3.rs-10046022/v1

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