Molecular surface mimicry enables CRBN to target G3BP2 for degradation

Abstract excerpt

Molecular glue degraders (MGDs) are small molecule compounds that repurpose the ubiquitin-proteasome system to induce degradation of challenging therapeutic targets. Clinically effective MGDs bind cereblon (CRBN), a substrate receptor of the Cullin-4/RING E3 ubiquitin ligase (CRL4CRBN), and impose a gain-of-function activity to recruit, ubiquitinate and degrade so-called neosubstrate proteins. Known neosubstrates...

Topics

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• CAR-T cell therapy research
• CRISPR and Genetic Engineering
• Multiple Myeloma Research and Treatments
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

b64df5f5-2762-56bd-8e4f-4b253f1aa417

DOI

10.1101/2025.04.30.651496