Article

De novo Design of Macrocyclic Molecular Glues

2026-08-22

Abstract excerpt

The engineering of induced proximity has transformed drug discovery, yet the development of molecular glues remains largely serendipitous and restricted to the retrospective optimisation of accidental discoveries. Here, we present EvoBind-multimer, a deep learning framework for the de novo design of molecular glues directly from protein sequences. Unlike structure-based docking, our method generates small macrocyc...

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Literature Corpus work: 74d6c126-13f0-51be-9204-44e555e8c7c6
DOI: 10.64898/2026.08.21.746227

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