Mapping the latent CRBN-molecular glue degrader interactome

Abstract excerpt

<h4>ABSTRACT</h4> Molecular glue degraders (MGDs) are a transformative modality in drug discovery. MGDs that work in concert with the E3 ligase CRL4 CRBN can degrade a range of substrates through tailored MGDs. To explore CRL4 CRBN reprogrammability, we tested whether reported CRBN-MGD substrates are part of a network of latent CRBN interactors, detectable with generic CRBN-MGDs. Leveraging highly parallel inte...

Topics

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• CAR-T cell therapy research
• CRISPR and Genetic Engineering
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

a9c0f89e-8e7f-50be-b59b-89724021d479

DOI

10.64898/2025.12.02.691773