Article

Chemoproteomics-Enabled Discovery of a Covalent Molecular Glue Degrader Targeting NF-κB

2022-05-18

Abstract excerpt

Targeted protein degradation using heterobifunctional Proteolysis-Targeting Chimeras (PROTACs) or molecular glues has arisen as a powerful therapeutic modality for degrading disease targets. While PROTAC design is becoming more modular and straightforward, the discovery of novel molecular glue degraders has been more challenging. While several recent studies have showcased phenotypic screening and counter-screenin...

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Literature Corpus work: 7c687ede-36fa-5909-834b-e7b746c08639
DOI: 10.1101/2022.05.18.492542

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