Article

Genome location dictates the transcriptional response to PolC-inhibition in <i>Clostridium difficile</i>

2018-07-04

Abstract excerpt

Clostridium difficile is a potentially lethal gut pathogen that causes nosocomial and community acquired infections. Limited treatment options and reports of reduced susceptibility to current treatment emphasize the necessity for novel antimicrobials. The DNA-polymerase of gram-positive organisms is an attractive target for the development of antimicrobials. ACX-362E ( N 2 -(3<,4-Dichlorobenzyl)-7-(2-[1-morpholin...

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Literature Corpus work: f6ffc57e-df38-52c4-bd5d-75090582fd61
DOI: 10.1101/362137

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