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Bacterial topoisomerase I as a target for discovery of antibacterial compounds.

Nucleic acids research - 1 Feb 2009

Tse-Dinh Yuk-Ching

Abstract excerpt

Bacterial topoisomerase I is a potential target for discovery of new antibacterial compounds. Mutant topoisomerases identified by SOS induction screening demonstrated that accumulation of the DNA cleavage complex formed by type IA topoisomerases is bactericidal. Characterization of these mutants of Yersinia pestis and Escherichia coli topoisomerase I showed that DNA religation can be inhibited while maintaining...

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Identifiers

PMID: 19042977
DOI: 10.1093/nar/gkn936
PMCID: PMC2647297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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