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Article

Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile.

Open biology - 1 Dec 2016

van Eijk Erika, Paschalis Vasileios, Green Matthew, Friggen Annemieke H, Larson Marilynn A, Spriggs Keith, Briggs Geoffrey S, Soultanas Panos, Smits Wiep Klaas

Abstract excerpt

DNA replication is an essential and conserved process in all domains of life and may serve as a target for the development of new antimicrobials. However, such developments are hindered by subtle mechanistic differences and limited understanding of DNA replication in pathogenic microorganisms. Clostridium difficile is the main cause of healthcare-associated diarrhoea and its DNA replication machinery is virtually...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28003473
DOI: 10.1098/rsob.160272
PMCID: PMC5204125

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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