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Clostridium difficile DNA Polymerase IIIC: Basis for Activity of Anti-Bacterial Compounds

1 Oct 2011

Abstract excerpt

Based on the finding that aerobic Gram-positive antibacterials that inhibit DNA polymerase IIIC (pol IIIC) were potent inhibitors of the growth of anaerobic Clostridium difficile (CD) strains, we chose to clone and express the gene for pol IIIC from this organism. The properties of the recombinant enzyme are similar to those of related pol IIICs from Gram-positive aerobes, e.g. B. subtilis. Inhibitors of the CD...

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Share to Bacterial Identification and Susceptibility Testing
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PMID: 22844265
DOI: 10.2174/157340811798807597

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