Article

The C-terminal domain of <i>Clostridioides difficile</i> TcdC is exposed on the bacterial cell surface

2019-12-11

Abstract excerpt

Clostridioides difficile is an anaerobic gram-positive bacterium that can can produce the large clostridial toxins, Toxin A and Toxin B, encoded within the pathogenicity locus (PaLoc). The PaLoc also encodes the sigma factor TcdR, that positively regulates toxin gene expression, and TcdC, a putative negative regulator of toxin expression. TcdC is proposed to be an anti-sigma factor, however, several studies failed...

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Literature Corpus work: 50572c1c-0291-52a0-b527-70cc5c028faf
DOI: 10.1101/872283

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