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Bacteriophage-Mediated Toxin Gene Regulation in <i>Clostridium difficile</i>

24 Sept 2009

Abstract excerpt

Clostridium difficile has been identified as the most important single identifiable cause of nosocomial antibiotic-associated diarrhea and colitis. Virulent strains of C. difficile produce two large protein toxins, toxin A and toxin B, which are involved in pathogenesis. In this study, we examined the effect of lysogeny by PhiCD119 on C. difficile toxin production. Transcriptional analysis demonstrated a decrease...

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Identifiers

PMID: 19776116
DOI: 10.1128/jvi.01256-09

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