FusionPDB: a unique knowledgebase of human fusion proteins of consistent annotation across genomic/ transcript/ protein/ interaction levels

Abstract excerpt

<title>Abstract</title> <p>Tumorigenic functions due to the formation of fusion genes were targeted for cancer therapeutics (i.e., kinase inhibitors). However, there are still many fusion proteins awaiting being targeted for therapeutics with multiple different mechanisms. Due to the lack of knowledge of the fusion protein sequence and 3D structure, there were not many studies available. To fill this gap, we deve...

Topics

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• Cancer Genomics and Diagnostics
• Cancer-related Molecular Pathways
• Gene Expression Regulation, Neoplastic
• Lung Cancer Treatments and Mutations
• Peptidase Inhibition and Analysis
• RNA and protein synthesis mechanisms
• RNA Research and Splicing
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

f6ff8c23-ffa4-530b-99be-2bf97023077f

DOI

10.21203/rs.3.rs-2188660/v1