Article

Targeted <i>in silico</i> characterization of fusion transcripts in tumor and normal tissues via FusionInspector

2021-08-04

Abstract excerpt

<h4>Motivation</h4> Gene fusions play a key role as driver oncogenes in tumors, and their reliable discovery and detection are important for cancer research, diagnostics, prognostics and guiding personalized therapy. While discovering gene fusions from genome sequencing can be laborious and costly, the resulting “fusion transcripts” can be recovered from RNA-seq data of tumor and normal samples. However, alleged...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 85b4af3a-167a-5dc2-bef2-5fef47cf0e7f
DOI: 10.1101/2021.08.02.454639

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeted <i>in silico</i> characterization of fusion transcripts in tumor and normal tissues via FusionInspectorDOI 10.1101/2021.08.02.454639Read

Improved detection of gene fusions by applying statistical methods reveals new oncogenic RNA cancer driversSemantic proximity Read

Systematic discovery of gene fusions in pediatric cancer by integrating RNA-seq and WGSSemantic proximity Read

Systematic discovery of gene fusions in pediatric cancer by integrating RNA-seq and WGSSemantic proximity Read

annoFuse: an R Package to annotate, prioritize, and interactively explore putative oncogenic RNA fusionsSemantic proximity Read

TumorFusions: an integrative resource for cancer-associated transcript fusions.Semantic proximity Read

annoFuse: an R Package to annotate, prioritize, and interactively explore putative oncogenic RNA fusionsSemantic proximity Read

Discovery of Clinically Relevant Fusions in Pediatric CancerSemantic proximity Read

ImmunoFusion: A Unified Platform for Investigating RNA-seq-Derived Gene Fusions in Cancer and ImmunotherapySemantic proximity Read

JAFFAL: Detecting fusion genes with long read transcriptome sequencingSemantic proximity Read

SFyNCS detects oncogenic fusions involving non-coding sequences in cancerSemantic proximity Read

Systematic discovery of gene fusions in pediatric cancer by integrating RNA-seq and WGSSemantic proximity Read

Comprehensive genome and transcriptome analysis reveals genetic basis for gene fusions in cancerSemantic proximity Read