Identification of gene fusions from human lung cancer mass spectrometry data

Abstract excerpt

BACKGROUND: Tandem mass spectrometry (MS/MS) technology has been applied to identify proteins, as an ultimate approach to confirm the original genome annotation. To be able to identify gene fusion proteins, a special database containing peptides that cross over gene fusion breakpoints is needed. METHODS: It is impractical to construct a database that includes all possible fusion peptides originated from potential...

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