Human Transcription Factor and Protein Kinase Gene Fusions in Human Cancer

Abstract excerpt

<h4>ABSTRACT</h4> Oncogenic gene fusions are estimated to account for up-to 20 % of cancer morbidity. Originally, oncofusions were identified in blood cancer, but recently multiple sequence-level studies of cancer genomes have established oncofusions throughout all tissue types. However, the functional implications of the identified oncofusions have often not been investigated. In this study, the identified oncof...

Topics

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• Cancer Genomics and Diagnostics
• Cancer-related Molecular Pathways
• Gene Expression Regulation, Neoplastic
• Gene Fusion
• High-Throughput Nucleotide Sequencing
• RNA and protein synthesis mechanisms
• RNA Research and Splicing
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

a2a15e35-9694-5b27-a3d7-a2b670198e56

DOI

10.1101/2020.04.09.033613