Article
The role of glycolysis and lactate in the induction of tumor-associated macrophages immunosuppressive phenotype.
International immunopharmacology - 1 Sept 2022
Zhang Yijia, Zhang Xue, Meng Yuting, Xu Xiaobo, Zuo Daiying
Abstract excerpt
Growing evidence highlights that glycolysis and tumor-derived lactate could skew tumor-associated macrophages (TAMs) toward an immunosuppressive phenotype. However, the updated research has not been systematically summarized yet. TAMs are educated by the tumor microenvironment (TME) and exert immunosuppressive functions and tumorigenic effects via multiple biological processes. It is well known that lactate...
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