Article

Quantitative proteomics reveals key roles for post-transcriptional gene regulation in the molecular pathology of FSHD

2018-09-14

Abstract excerpt

DUX4 is a transcription factor whose misexpression in skeletal muscle causes facioscapulohumeral muscular dystrophy (FSHD). While DUX4’s transcriptional activity has been extensively characterized, the DUX4-induced proteome remains undescribed. Here, we report concurrent measurement of RNA and protein levels in DUX4-expressing cells via RNA-seq and quantitative mass spectrometry. DUX4 transcriptional targets were...

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Literature Corpus work: 3730e944-d490-502b-8cb3-c17acfe7f58c
DOI: 10.1101/417790

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