Article

Cross-Tissue Epigenetic Age Prediction with Compact CpG Panels

2026-02-25

Abstract excerpt

<title>Abstract</title> <p>Epigenetic age estimators based on DNA methylation provide powerful biomarkers of aging, but most clocks are tissue‑specific and rely on large CpG panels. Here we develop compact, interpretable machine learning models that capture age‑related DNA methylation patterns in human brain and blood, and we evaluate their cross‑tissue behavior using public Illumina 450K datasets. Using frontal...

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Literature Corpus work: f67a37b9-0973-5ba7-86fa-bc4096f88f76
DOI: 10.21203/rs.3.rs-8928610/v1

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