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Long-Read epigenetic clocks identify improved brain aging predictions

2025-10-03

Abstract excerpt

Epigenetic clocks are widely used to estimate biological aging, yet most are built from array-based data from peripheral tissues of predominantly European-ancestry individuals, limiting generalizability. Here, we present aging clocks trained using GenoML, an automated machine learning platform for clinical and multiomics data, on DNA methylation from Oxford Nanopore long-read sequencing. These models leverage over...

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Literature Corpus work
34094fc6-5df5-5814-b673-8f34b3fc271a
DOI
10.1101/2025.09.30.679553
Open publication

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Long-Read epigenetic clocks identify improved brain aging predictionsDOI 10.1101/2025.09.30.679553
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