Article
Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex.
Brain : a journal of neurology - 1 Dec 2020
Shireby Gemma L, Davies Jonathan P, Francis Paul T, Burrage Joe, Walker Emma M, Neilson Grant W A, Dahir Aisha, Thomas Alan J, Love Seth, Smith Rebecca G, Lunnon Katie, Kumari Meena, Schalkwyk Leonard C, Morgan Kevin, Brookes Keeley, Hannon Eilis, Mill Jonathan
Abstract excerpt
Human DNA methylation data have been used to develop biomarkers of ageing, referred to as 'epigenetic clocks', which have been widely used to identify differences between chronological age and biological age in health and disease including neurodegeneration, dementia and other brain phenotypes. Existing DNA methylation clocks have been shown to be highly accurate in blood but are less precise when used in older...
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