Article

Recalibrating the Epigenetic Clock: Implications for Assessing Biological Age in the Human Cortex

2020-04-28

Abstract excerpt

Human DNA-methylation data have been used to develop biomarkers of ageing - referred to ‘epigenetic clocks’ - that have been widely used to identify differences between chronological age and biological age in health and disease including neurodegeneration, dementia and other brain phenotypes. Existing DNA methylation clocks are highly accurate in blood but are less precise when used in older samples or on brain ti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bea6217d-647f-599a-ae3b-99a3a6e4d9ba
DOI: 10.1101/2020.04.27.063719

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Recalibrating the Epigenetic Clock: Implications for Assessing Biological Age in the Human CortexDOI 10.1101/2020.04.27.063719Read

Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex.Semantic proximity Read

Properties of the epigenetic clock and age accelerationSemantic proximity Read

AltumAge: A Pan-Tissue DNA-Methylation Epigenetic Clock Based on Deep LearningSemantic proximity Read

Long-Read epigenetic clocks identify improved brain aging predictionsSemantic proximity Read

A Network Approach to DNA Methylation ClocksSemantic proximity Read

Quantification of the pace of biological aging in humans through a blood test: The DunedinPoAm DNA methylation algorithmSemantic proximity Read

Time is encoded by methylation changes at clustered CpG sitesSemantic proximity Read

DNA methylation clocks for estimating biological age in Chinese cohortsSemantic proximity Read

Insights into ageing rates comparison across tissues from recalibrating cerebellum DNA methylation clockSemantic proximity Read

Aging the Brain: Multi-Region Methylation Principal Component Based Clock in the Context of Alzheimer’s DiseaseSemantic proximity Read

Aging the brain: multi-region methylation principal component based clock in the context of Alzheimer’s diseaseSemantic proximity Read

DNA methylation age from peripheral blood predicts progression to Alzheimer’s disease, white matter disease burden, and cortical atrophySemantic proximity Read