Article
Time is encoded by methylation changes at clustered CpG sites
2024-12-05
Abstract excerpt
Age-dependent changes in DNA methylation allow chronological and biological age inference, but the underlying mechanisms remain unclear. Using ultra-deep sequencing of >300 blood samples from healthy individuals, we show that age-dependent DNA methylation changes are regional and occur at multiple adjacent CpG sites, either stochastically or in a coordinated block-like manner. Deep learning analysis of single-mole...
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Identifiers and source
- Literature Corpus work
- 58df3278-670d-5de3-aca0-bc64d34f1e79
- DOI
- 10.1101/2024.12.03.626674