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SHAP‑Guided CpG Selection with Ensemble Learning for Epigenetic Age Prediction

2026-02-23

Abstract excerpt

Epigenetic biomarkers offer critical insight into biological aging and disease risk, yet most deep learning models lack interpretability and generalization across tissues. We present a reproducible pipeline for interpretable age classification using SHAP-guided CpG prioritization, enhancer and gene annotation, and stacked ensemble modeling. Across both blood and brain samples (GSE41826, GSE40279), certain CpGs sho...

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Identifiers and source

Literature Corpus work
90ce08be-6907-5a92-ac18-4f044a1ac216
DOI
10.64898/2026.02.20.707142
Open publication

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SHAP‑Guided CpG Selection with Ensemble Learning for Epigenetic Age PredictionDOI 10.64898/2026.02.20.707142
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