Article

MethylGPT: a foundation model for the DNA methylome

2024-11-03

Abstract excerpt

DNA methylation serves as a powerful biomarker for disease diagnosis and biological age assessment. However, current analytical approaches often rely on linear models that cannot capture the complex, context-dependent nature of methylation regulation. Here we present MethylGPT, a transformer-based foundation model trained on 226,555 (154,063 after QC and deduplication) human methylation profiles spanning diverse t...

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Literature Corpus work: 515fbb0b-01da-5ae4-823b-84c415535926
DOI: 10.1101/2024.10.30.621013

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