Article

Constitutive signal bias mediated by the human GHRHR splice variant 1

2021-08-20

Abstract excerpt

Alternative splicing of G protein-coupled receptors has been observed, but their functions are largely unknown. Here, we report that a splice variant (SV1) of the human growth hormone releasing hormone receptor (GHRHR) is capable of transducing biased signal. Differing only at the receptor N terminus, GHRHR predominantly activates G s while SV1 selectively couples to β-arrestins. Based on the cryo-electron micros...

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Literature Corpus work: f66f6455-2e4e-5eda-b29f-de5d6de24668
DOI: 10.1101/2021.08.20.457043

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