Article
Biased signaling of the angiotensin II type 1 receptor can be mediated through distinct mechanisms.
PloS one - 30 Nov 2010
Bonde Marie Mi, Hansen Jonas Tind, Sanni Samra Joke, Haunsø Stig, Gammeltoft Steen, Lyngsø Christina, Hansen Jakob Lerche
Abstract excerpt
BACKGROUND: Seven transmembrane receptors (7TMRs) can adopt different active conformations facilitating a selective activation of either G protein or β-arrestin-dependent signaling pathways. This represents an opportunity for development of novel therapeutics targeting selective biological effects of a given receptor. Several studies on pathway separation have been performed, many of these on the Angiotensin II...
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