Article
Constitutive signal bias mediated by the human GHRHR splice variant 1.
Proceedings of the National Academy of Sciences of the United States of America - 5 Oct 2021
Cong Zhaotong, Zhou Fulai, Zhang Chao, Zou Xinyu, Zhang Huibing, Wang Yuzhe, Zhou Qingtong, Cai Xiaoqing, Liu Qiaofeng, Li Jie, Shao Lijun, Mao Chunyou, Wang Xi, Wu Jihong, Xia Tian, Zhao Li-Hua, Jiang Hualiang, Zhang Yan, Xu H Eric, Cheng Xi, Yang Dehua, Wang Ming-Wei
Abstract excerpt
Alternative splicing of G protein-coupled receptors has been observed, but their functions are largely unknown. Here, we report that a splice variant (SV1) of the human growth hormone-releasing hormone receptor (GHRHR) is capable of transducing biased signal. Differing only at the receptor N terminus, GHRHR predominantly activates Gs while SV1 selectively couples to β-arrestins. Based on the cryogenic electron...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.