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Article

Biased Signaling and Allosteric Modulation at the FSHR

13 Mar 2019

Abstract excerpt

Knowledge on G protein-coupled receptor (GPCRs) structure and mechanism of activation has profoundly evolved over the past years. The way drugs targeting this family of receptors are discovered and used has also changed. Ligands appear to bind a growing number of GPCRs in a competitive or allosteric manner to elicit balanced signaling or biased signaling (i.e., differential efficacy in activating or inhibiting...

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PMID: 30930853
DOI: 10.3389/fendo.2019.00148

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