Article

Molecular mechanism of naturally-encoded signaling-bias at the complement anaphylatoxin receptors

2025-11-01

Abstract excerpt

The conceptual framework of biased signaling has revolutionized our understanding of GPCR signaling and regulatory paradigms, and greatly impacted the efforts focused on the discovery of GPCR-targeted therapeutics. However, the mechanistic basis of biased signaling remains primarily defined based on synthetic ligands and receptor mutants with relatively limited progress in understanding naturally-encoded signaling...

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Literature Corpus work: a523cab3-365e-54ae-95bf-ea18dad3f284
DOI: 10.1101/2025.11.01.685996

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