Article

CGRP-receptor family reveals endogenous GPCR agonist bias and its significance in primary human cardiovascular cells

2020-12-22

Abstract excerpt

Agonist bias at G protein-coupled receptors has attracted considerable interest, although its relevance for physiologically-produced agonists is not always clear. Here, using primary human cells and gene editing techniques, we demonstrate for the first time, endogenous agonist bias with physiological consequences for the calcitonin-like receptor (CLR). We reveal that by switching the accessory protein: receptor ac...

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Identifiers and source

Literature Corpus work: 37d0178e-2f85-5021-9b0d-afdc5bf30325
DOI: 10.1101/2020.12.21.423730

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