Article

A heterozygous <i>CEBPA</i> mutation disrupting the bZIP domain causes MDS disease progression

2023-07-26

Abstract excerpt

<h4>SUMMARY</h4> Myelodysplastic syndrome disease (MDS) has a variable risk for progression to AML. Mutations in CEBPA are associated with a high risk of disease progression, but whether this mutation is causative for AML development is unclear. To answer this question, we generated patient-derived, MDS-specific iPSCs recapitulating the patient disease phenotype upon differentiation to blood, with hematopoietic...

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Literature Corpus work: 8f5022e6-4314-5350-836d-c26118ed74f4
DOI: 10.1101/2023.07.24.550349

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