Article

Vaccination with a Replication-Dead Murine Gammaherpesvirus Lacking Viral Pathogenesis Genes Inhibits WT Virus Infection

2024-11-21

Abstract excerpt

Gammaherpesviruses are oncogenic pathogens that establish lifelong infections. There are no FDA-approved vaccines against Epstein-Barr virus or Kaposi sarcoma herpesvirus. Murine gammaherpesvirus-68 (MHV68) infection of mice provides a system for investigating of gammaherpesvirus pathogenesis and testing vaccine strategies. Prime-boost vaccination with a replication-dead virus (RDV) that does not express the essen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f6577103-e292-505a-9e96-5642fd1d28fc
DOI: 10.1101/2024.11.20.624603

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Vaccination with a Replication-Dead Murine Gammaherpesvirus Lacking Viral Pathogenesis Genes Inhibits WT Virus InfectionDOI 10.1101/2024.11.20.624603Read

Replication-dead gammaherpesvirus vaccine protects against acute replication, reactivation from latency, and lethal challenge in miceSemantic proximity Read

A gammaherpesvirus 68 gene 50 null mutant establishes long-term latency in the lung but fails to vaccinate against a wild-type virus challenge.Semantic proximity Read

Virus-encoded microRNAs facilitate gammaherpesvirus latency and pathogenesis in vivo.Semantic proximity Read

Generation of a Latency-Deficient Gammaherpesvirus That Is Protective against Secondary InfectionSemantic proximity Read

Conquering the Host: Determinants of Pathogenesis Learned from Murine Gammaherpesvirus 68Semantic proximity Read

Lytic Replication and Reactivation from B Cells Is Not Required for Maintaining Gammaherpesvirus Latency <i>in vivo</i>Semantic proximity Read

Deletion of immune evasion genes provides an effective vaccine design for tumor-associated herpesvirusesSemantic proximity Read

Murine gammaherpesvirus 68 lacking thymidine kinase shows severe attenuation of lytic cycle replication in vivo but still establishes latency.Semantic proximity Read

Protection against wild-type murine gammaherpesvirus-68 latency by a latency-deficient mutant.Semantic proximity Read

Gammaherpesvirus Small Noncoding RNAs Are Bifunctional Elements That Regulate Infection and Contribute to Virulence <i>In Vivo</i>Semantic proximity Read

The amplitude of gammaherpesvirus lytic replication dictates adaptive immune activation: Potential implications for KSHV LANA in immune evasionSemantic proximity Read