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Generation of a Latency-Deficient Gammaherpesvirus That Is Protective against Secondary Infection

13 Aug 2004

Abstract excerpt

Kaposi's sarcoma-associated herpesvirus and murine gammaherpesvirus-68 (MHV-68) establish latent infections and are associated with various types of malignancies. They are members of the gamma-2 herpesvirus subfamily and encode a replication and transcriptional activator, RTA, which is necessary and sufficient to disrupt latency and initiate the viral lytic cycle in vitro. We have constructed a recombinant MHV-68...

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Identifiers

PMID: 15308716
DOI: 10.1128/jvi.78.17.9215-9223.2004

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Generation of a Latency-Deficient Gammaherpesvirus That Is Protective against Secondary InfectionPMID 15308716Read ↗

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