Article

The amplitude of gammaherpesvirus lytic replication dictates adaptive immune activation: Potential implications for KSHV LANA in immune evasion

2026-02-05

Abstract excerpt

<h4>ABSTRACT</h4> Adaptive immune responses to primary Kaposi sarcoma-associated herpesvirus (KSHV) infection are poorly defined. To develop better small-animal models for understanding KSHV pathogenesis and immunity, we previously generated a chimeric virus in which the KSHV latency-associated nuclear antigen (kLANA), a conserved multifunctional protein critical for viral latency, was exchanged for the LANA homo...

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Literature Corpus work: d13eeb55-9207-5875-8824-145f71399c09
DOI: 10.64898/2026.02.05.703987

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